Partial end organ resistance to thyroid hormone in congenital hypothyroidism

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Partial end organ resistance to thyroid hormone in congenital hypothyroidism.

End organ resistance to thyroid hormone has been described for a number of years: the defect may be partial or generalized. A case of partial end organ resistance to thyroid hormone in congenital hypothyroidism is described, with evidence of an alteration in TSH threshold to feedback inhibition by thyroid hormone. The implications of this factor in the management of hypothyroidism are discussed.

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Partial target organ resistance to thyroid hormone.

An 8-year old boy with a small goiter, normal basal metabolic rate (BMR), and elevated serum thyroid hormone levels (thyroxine [T(4)] 19.5 mug per 100 ml, free T(4) 4 ng per 100 ml, triiodothyronine [T(3)] 505 ng per 100 ml) was studied. He had measurable serum thyroid-stimulating hormone (TSH) levels (average 5.5 muU per ml), and the thyroxine-binding proteins, hearing, and epiphyseal structur...

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Increased plasma thyroid stimulating hormone in treated congenital hypothyroidism: relation

Plasma thyroid stimulating hormone (TSH) concentrations obtained during the first four years of treatment in 418 children with congenital hypothyroidism, identified by neonatal screening, were examined in relation to paired measurements of plasma thyroxine (n= 1945), free thyroxine (n=836), triiodothyronine (n=480), and free triiodothyronine (n=231), and estimated daily dose of thyroxine at the...

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Ramadan Fasting and Thyroid Hormone Levels in Women with Hypothyroidism

Introduction: According to some studies, Ramadan fasting causes minimal changes in the levels of thyroid hormones. The present study aimed to evaluate the impact of Ramadan fasting on the levels of thyroid hormones in fasting women with hypothyroidism and levothyroxine intake. Methods: Serum levels of free thyroxine (T4) and thyroid-stimulating hormone (TSH) we...

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Congenital Hypothyroidism and Thyroid Cancer

Congenital hypothyroidism (CH) is a condition of thyroid hormone deficiency present at birth and can result in severe neurodevelopmental impairment, growth failure and permanent mental retardation if treatment is delayed for several months after birth (1-3). Girls are more frequently affected than boys (female to male ratios ranging from 2:1 to 4:1)(4). The mental retardation and neurodevelopme...

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ژورنال

عنوان ژورنال: Postgraduate Medical Journal

سال: 1981

ISSN: 0032-5473

DOI: 10.1136/pgmj.57.670.518